TCB Publications - Abstract

En Cai, Pinghua Ge, Sang Hak Lee, Okunola Jeyifous, Yong Wang, Yanxin Liu, Katie Wilson, Sung Jun Lim, Michelle Baird, John Stone, Kwan Young Lee, Michael Davidson, Hee Jung Chung, Klaus Schulten, Andrew Smith, William Green, and Paul R. Selvin. Stable small quantum dots for synaptic receptor tracking on live neurons. Angewandte Chemie - International Edition in English, 126:12692-12696, 2014. (PMC: PMC4240739)

CAI2014 We developed a coating method to produce functionalized small quantum dots (sQDs), $\sim$9 nm in diameter, that were stable for over a month. We made sQDs in four emission wavelengths, from 527 nm to 655 nm and with different functional groups. AMPA receptors on live neurons were labeled with sQDs and post-synaptic density proteins were visualized with super-resolution microscopy. Their diffusion behavior indicates that sQDs access the synaptic clefts significantly more often than commercial QDs.

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