TCB Publications - Abstract

Chaitanya Sathe, Xueqing Zou, Jean-Pierre Leburton, and Klaus Schulten. Computational investigation of DNA detection using graphene nanopores. ACS Nano, 5:8842-8851, 2011. (PMC: 3222720)

SATH2011 Nanopore-based single-molecule detection and analysis have been pursued intensively over the past decade. One of the most promising applications in this regard is DNA sequencing achieved through DNA translocation-induced blockades in ionic current. Recently, nanopores fabricated in graphene sheets were used to detect double-stranded DNA. Due to its sub-nanometer thickness, graphene nanopores show great potential to realize DNA sequencing at single-base resolution. Resolving at the atomic level electric field-driven DNA translocation through graphene nanopores is crucial to guide the design of graphene-based sequencing devices. Molecular dynamics simulations, in principle, can achieve such resolution and are employed here to investigate the effects of applied voltage, DNA conformation and sequence as well as pore charge on the translocation characteristics of DNA. We demonstrate that such simulations yield current characteristics consistent with recent measurements and suggest that under suitable bias conditions A-T and G-C base pairs can be discriminated using graphene nanopores.

Download Full Text

The manuscripts available on our site are provided for your personal use only and may not be retransmitted or redistributed without written permissions from the paper's publisher and author. You may not upload any of this site's material to any public server, on-line service, network, or bulletin board without prior written permission from the publisher and author. You may not make copies for any commercial purpose. Reproduction or storage of materials retrieved from this web site is subject to the U.S. Copyright Act of 1976, Title 17 U.S.C.

Download full text: Supplemental Material ( 1.3MB) - Supplementary PDF, Supplemental Material ( 1.2MB) - Supplementary movie S1, Supplemental Material ( 1.6MB) - Supplementary movie S2, Supplemental Material ( 1.5MB) - Supplementary movie S3, Supplemental Material ( 1.5MB) - Supplementary movie S4, Supplemental Material ( 2.5MB) - Supplementary movie S5, Supplemental Material ( 7.9MB) - Supplementary movie S6, Supplemental Material ( 8.2MB) - Supplementary movie S7, Request a Copy, Journal