Highlights of our Work
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For newly made membrane proteins, getting to their final destination in the membrane requires another protein, the channel SecY, to provide a pathway (see the Sept. 2007 and Feb. 2011 highlights). But just knowing the route is not enough, because SecY presents the nascent protein with a choice: insert into the membrane or cross the channel to the watery exterior. How the nascent protein comes to a decision has long been a point of uncertainty, although it has been presumed to be driven by purely energetic considerations, i.e., the protein goes to the environment it ultimately prefers. Now, recent simulations and free-energy calculations spanning time scales from nanoseconds all the way to seconds have revealed that how long the nascent protein deliberates in the channel is just as great a factor in its final location as how favorable it is there. It was found that the longer the protein takes to decide, the more likely it is to choose the membrane, proving that, at least for membrane insertion, slow and steady wins out. More information can be found on the protein translocation website.