Highlights of our Work

2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001

Stretching FN-III-10

image size: 78.8KB
made with VMD

Mechanical force is seen today as a key component of molecular processes in cells: forces can be signals as in touch receptors, products as in muscle action, and substrates as in the matrix surrounding moving cells . This view of molecular processes is the result of a series of ground-breaking investigations that have become possible only recently and is rapidly turning into a new field, mechanobiology (see recent review). A collaboration with V. Vogel and coworker (U. Washington, Seattle) has investigated structural changes accompanying stretch-induced unfolding events in type III fibronectin, a protein of the extracellular matrix, explaining the design of these proteins.